Anti-KEAP1 Antibody, Rabbit Polyclonal

产品编号：PA00470HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-KEAP1 Antibody, Rabbit Polyclonal

经验证的应用：WB/IHC/ICC
 
交叉反应：/
 
特异性：human KEAP1
 
免疫原：Recombinant human KEAP1 protein, fragment Met1~Gln286; UniprotKB: Q14145

制备方法：Produced in rabbits immunized with human KEAP1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：INrf2, KLHL19, Cytosolic inhibitor of Nrf2, Kelch-like protein 19
 
背景信息：KEAP1, also named as INRF2, KIAA0132 and KLHL19, is part of a multiprotein complex that contains the CUL3-ROC1 ubiquitin ligase, which can ubiquitinate the N-terminal domain of NRF2[PMID: 20173742]. Two molecules of KEAP1 bind to two distinct sites in the N-terminal region of NRF2, the ETGE and DLG sites, which affect the KEAP1-NRF2 interaction and/or its physiological consequences[PMID: 22215675]. KEAP1 retains NFE2L2/NRF2 in the cytosol. It functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1[PMID: 20427290]. It also retains BPTF in the cytosol.  This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1. Read more about this antibody on the blog:http://blog.ptglab.com/index.php/nsclc-research-anti-keap1-antibody-helps-uncover-targets-biomarker-potential.

全称：Kelch-like ECH-associated protein 1 (KEAP1)

说明书：待上传