Anti-NUDT5 Antibody, Rabbit Polyclonal

产品编号:PA00486HuA10
   
询价

规格     50uL  100uL  200uL
产品名称Anti-NUDT5 Antibody, Rabbit Polyclonal

经验证的应用WB/ICC
 
交叉反应Hu
 
特异性human NUDT5
 
免疫原Recombinant human NUDT5 protein, fragment Met1~Phe219; UniprotKB: Q9UKK9

制备方法Produced in rabbits immunized with human NUDT5, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片:







Figure1.Western blot analysis of extracts of various cell lines  using NUDT5 antibody (PA00486HuA10) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L)  at 1:10000 dilution. 








别称NUDIX5
 
背景信息ADP-Sugar Pyrophosphatase/NUDT5. ADP-Sugar Pyrophosphatase (NUDT5) is a member of the nudix superfamily of enzymes. Members of this family are pyrophosphohydrolases that act upon substrates with the general structure of a nucleoside (Nu) diphosphate (di) linked to another moiety, X (NDP-X) to yield NMP plus P-X (1). Human NUDT5 is a homodimeric enzyme present in the cytosol of most cell types (2). Glu166 and three magnesium ions are important for stabilizing the transition state during the hydrolysis of ADPR (3). NUDT5 has been suggested to play a role in regulating the intracellular levels of ADPR by NO activation through ADP-ribosylation at cysteine residues of the enzyme in macrophages (4). It also may play defensive role against the mutagenesis induced by oxidized deoxyribonucleosides (5, 6).

全称ADP-sugar pyrophosphatase (NUDT5)

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