Anti-BCL2 Antibody, Rabbit Polyclonal

产品编号:PA00081HuA10
   
询价

规格     50uL  100uL  200uL

产品名称Anti-BCL2 Antibody, Rabbit Polyclonal

经验证的应用/
 
交叉反应/
 
特异性human BCL2
 
免疫原Recombinant human BCL2 protein, fragment Met1~Lys 239; UniprotKB: P10415
 
制备方法Produced in rabbits immunized with human BCL2, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称B-Cell CLL/Lymphoma 2
 
背景信息Bcl-2. Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability (1, 2). Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-2, missing the mitochondrial targeting sequence, maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-2 appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.
 
全称Apoptosis regulator Bcl-2 (BCL2)
 
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