Anti-SIRT1 Antibody, Rabbit Polyclonal

产品编号：PA00082HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-SIRT1 Antibody, Rabbit Polyclonal

经验证的应用：IHC/IF/ICC
 
交叉反应：Ra
 
特异性：human SIRT1
 
免疫原：Recombinant human SIRT1 protein, fragment Glu244~Ala498; UniprotKB: Q96EB6
 
制备方法：Produced in rabbits immunized with human SIRT1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

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别称：SIR2L1, Silent Mating Type Information Regulation 2 Homolog 1, NAD-Dependent Deacetylase Sirtuin-1, SIR2-like protein 1, SirtT1 75 kDa fragment
 
背景信息：Sirtuin 1/SIRT1. SIRT1 is an NAD+-dependent class III histone deacetylase. It is a member of the sirtuin family of proteins, homologous to the yeast Sir2 protein. It modulates intracellular activities through transcription regulation and functions in several separate cellular functions. SIRT1 deacetylates and inactivates tumor suppressor protein p53, a process regulated by Hypermethylated in Cancer 1 (HIC1) protein to allow cells to bypass apoptosis and survive DNA damage (1, 2). The level of SIRT1 is significantly elevated in mouse and human prostate cancer (3). SIRT1 promotes vascular relaxation by activating endothelial nitric oxide synthase (4). SIRT1 also protects against microglia‑dependent amyloid-beta toxicity through inhibiting NF-Kappa b signaling (5).
 
全称：NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
 
说明书：待上传