Anti-PDGFRA Antibody, Rabbit Polyclonal

产品编号：CP00505HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-PDGFRA Antibody, Rabbit Polyclonal

经验证的应用：ICC
 
交叉反应：/
 
特异性：human PDGFRA
 
免疫原：Recombinant human PDGFRA protein, fragment Gln24~Ala528; UniprotKB: P16234

制备方法：Produced in rabbits immunized with human PDGFRA, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片：
 



别称：CD140a, PDGFR2, Rhe-PDGFRA, CD140 antigen-like family member A, Platelet-derived growth factor receptor 2, Alpha-type platelet-derived growth factor receptor
 
背景信息：PDGF R alpha. PDGF R alpha  (platelet-derived growth factor receptor alpha) is a type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTK) (1 ‑ 4). PDGF R alpha  and PDGF R beta  can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, which include disulfide-linked homodimers of PDGF-A, B, C or D, or the heterodimer PDGF-AB that is mainly found in human platelets. While multiple in vitro ligand-receptor combinations have been identified, in vivo evidence indicates that PDGF R alpha  primarily binds PDGF-AA and PDGF-CC, while PDGF R beta  primarily binds PDGF-BB and probably PDGF-DD. Like all class III RTKs, the extracellular domain (ECD) of human PDGF R alpha  (aa 24 ‑ 524) contains five immunoglobulin-like domains, while the intracellular region contains a split tyrosine kinase domain (aa 593 ‑ 954) (1 ‑ 4). Within the ECD, human PDGF R alpha  shares 85%, 83%, 95%, 93%, and 88% aa sequence identity with mouse, rat, equine, canine and bovine PDGF R alpha  respectively. PDGF R alpha  autophosphorylates upon dimerization, activating signaling cascades in PI 3-kinase Ras‑MAP kinase, and PLC-gamma  pathways (1, 2). Signaling is down‑regulated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. PDGF R alpha  is expressed at low levels in most mesenchymal cells, but is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture (1 ‑ 4). During development, mesenchymal cells expressing PDGF R alpha  respond to local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial and cardiac neural crest, retina, gonads, lung alveoli, intestinal villi, skin, hair follicles, skeleton, teeth, palate, and interstitial kidney mesenchyme (1, 5). Deletion of PDGF R alpha  in mice severely impairs mesenchymal derivatives in both embryo and extraembryonic tissues, and high or low PDGF R alpha  signaling in humans may result in spina bifida or cleft palate‑type malformations. Postnatally, PDGF R alpha  is implicated in gliomas and fibrotic disorders of lung, heart and skin (scleroderma) (6 ‑ 8).

全称：Platelet-derived growth factor receptor alpha (PDGFRA)

说明书：待上传