Anti-IGF1R Antibody, Rabbit Polyclonal

产品编号:PA00508HuA10
   
询价

规格     50uL  100uL  200uL

产品名称Anti-IGF1R Antibody, Rabbit Polyclonal

经验证的应用/
 
交叉反应/
 
特异性human IGF1R
 
免疫原Recombinant human IGF1R protein, fragment Asp741~His935; UniprotKB: P08069

制备方法Produced in rabbits immunized with human IGF1R, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

图片:


Figure1.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human  gastric cancer  sections labelling IGF1R with purified PA00508HuA10 at 10ug/ml. Heat mediated antigen retrieval was performed using Heat mediated antigen retrieval using Bond™ Epitope Retrieval Solution  (EDTA, pH 9.0).  Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.




 


Figure2.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human  breast cancer  sections labelling IGF1R with purified PA00508HuA10 at 10ug/ml. Heat mediated antigen retrieval was performed using Heat mediated antigen retrieval using Bond™ Epitope Retrieval Solution  (EDTA, pH 9.0).  Tissue was counterstained with Hematoxylin. Rabbit specific IHC polymer detection kit HRP/DAB secondary antibody was used at 1/4000 dilution. PBS instead of the primary antibody was used as the negative control.



 
别称CD221, IGF1-R, IGFIR, JTK13
 
背景信息IGF-I R/IGF1R. IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two  alpha  and two  beta  subunits. Both the  alpha  and  beta  subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The  alpha  subunit of IGF-I receptor is extracellular while the  beta  subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R.

全称Insulin-like growth factor 1 receptor (IGF1R)

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