Anti-KLRK1 Antibody, Rabbit Polyclonal

产品编号：PA00509HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-KLRK1 Antibody, Rabbit Polyclonal

经验证的应用：WB/IHC
 
交叉反应：/
 
特异性：human KLRK1
 
免疫原：Recombinant human KLRK1 protein, fragment Ile73~Val216; UniprotKB: P26718

制备方法：Produced in rabbits immunized with human KLRK1, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：CD314, KLR-K1, KLR, NKG2-D, NKG2-D Type II Integral Membrane Protein, NK cell receptor D, NKG2-D-activating NK receptor
 
背景信息：NKG2D/CD314. NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8+  alpha  beta  T cells,  gamma δ T cells, NK cells and NKT cells. In mouse systems NKG2D also occurs on macrophages. Human ligands for NKG2D include MICA, MICB, and ULBP1, 2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. Signaling requires association with an adapter protein. Alternative splicing of the NKG2D mRNA results in isoforms with different cytoplasmic domains that can associate either with DAP12 to deliver a true activating signal or with DAP10 resulting in a costimulatory signal. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection.

全称：NKG2-D type II integral membrane protein (KLRK1)

说明书：待上传