Anti-IL22 Antibody, Rabbit Polyclonal

产品编号：PA00512HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-IL22 Antibody, Rabbit Polyclonal

经验证的应用：/
 
交叉反应：/
 
特异性：human IL22
 
免疫原：Recombinant human IL22 protein, fragment Ala34~Ile179; UniprotKB: Q9GZX6

制备方法：Produced in rabbits immunized with human IL22, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称：ILTIF, Zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23, IL-22, Cytokine Zcyto18, IL-10-Related T-Cell-Derived Inducible Factor
 
背景信息：IL-22. Interleukin-22 (IL-22), also known as IL-10-related T cell-derived inducible factor (IL-TIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Human IL-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79% and 22% aa sequence identity with mouse IL-22 and human IL-10, respectively. The human IL-22 gene is localized to chromosome 12q15. Although it exists as a single copy gene in human and in many mouse strains, the mouse IL-22 gene is duplicated in some mouse strains including C57B1/6, FVB and 129. The two mouse genes designated IL-TIF alpha  and IL-TIF beta, share greater than 98% sequence homology in their coding region. IL-22 has been shown to activate STAT‑1 and STAT-3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta  (previously known as CRF2-4), belonging to the class II cytokine receptor family.

全称：Interleukin-22 (IL22)

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