Anti-FOXO3 Antibody, Rabbit Polyclonal

产品编号:PA00122HuA10
   
询价

规格     50uL  100uL  200uL

产品名称Anti-FOXO3 Antibody, Rabbit Polyclonal

经验证的应用WB/IHC/IF/ICC
 
交叉反应/
 
特异性human FOXO3
 
免疫原Recombinant human FOXO3 protein, fragment Leu369~Met633; UniprotKB: O43524
 
制备方法Produced in rabbits immunized with human FOXO3, and purified by antigen affinity chromatography.

来源Polyclonal Rabbit IgG
 
纯化Immunogen affinity purified
 
缓冲液Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物Unconjugated
 
状态Liquid
 
运输方式This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
 
别称FOX-O3, FOX2, FOXO3A, FKHRL1, FKHRL1P2, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1
 
背景信息In mammalian cells, FoxO factors act as potent transcriptional activators that upregulate the expression of programs of genes involved in stress resistance, cell cycle arrest, differentiation, apoptosis, autophagy, and metabolism. FOXO3 has a key role in the maintenance of adult neural and hematopoietic stem cells. It also associates with extreme longevity in humans and regulates the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. Phosphorylation inhibits FOXO3 nuclear translocation that is essential for its regulation and function. The calculated molecular weight of FOXO3 is 71 kDa,but some experiments analysis using a FOXO3a specific antibody showed the expression of a 90 kDa fulllength FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short). 90 kDa FOXO3a protein is a phosphorylated via activation of PI3K (phosphatidylinositol 3-kinase) and Akt after INS stimulation, and translocate from the nucleus to the cytoplasm. (PMID: 19427386)
 
全称Forkhead box protein O3 (FOXO3)
 
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