Anti-CDKN1B Antibody, Rabbit Polyclonal

产品编号：PA00157HuA10
   
$ 询价

规格     50uL  100uL  200uL

产品名称：Anti-CDKN1B Antibody, Rabbit Polyclonal

经验证的应用：WB/IHC/ICC
 
交叉反应：Hu
 
特异性：human CDKN1B
 
免疫原：Recombinant human CDKN1B protein, fragment Met1~Thr198; UniprotKB: P46527
 
制备方法：Produced in rabbits immunized with human CDKN1B, and purified by antigen affinity chromatography.

来源：Polyclonal Rabbit IgG
 
纯化：Immunogen affinity purified
 
缓冲液：Supplied in PBS, 50% glycerol and less than 0.02% sodium azide, PH7.4
 
偶联物：Unconjugated
 
状态：Liquid
 
运输方式：This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended.
 
储存条件：This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

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别称：CDKN4, KIP1, P27KIP1, p27, Cyclin-dependent kinase inhibitor p27
 
背景信息：CDKN1B, also named as P27 or KIP1, is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. P27 binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controlling cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Downregulation of P27 has been implicated in the progression of several malignancies, including lung cancer, hepatocellular carcinoma, salivary cancer, oral squamous cell carcinomas, and gastric cancer.
 
全称：Cyclin-dependent kinase inhibitor 1B (CDKN1B)
 
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